Washington, Feb 24 (PTI) Scientists have identified a drug that extends egg viability in worms and could theoretically extend women’s fertility by three to six years. Also Read - Three Dead, 4 Injured in House Party Shooting in North Carolina
“As early as the mid-30s, women start to experience declines in fertility, increased rates of miscarriage and maternal age-related birth defects,” said Coleen Murphy from the Princeton University in the US. Also Read - 'Another Phase of Greatest Witch Hunt', Says Donald Trump After US Senate Acquits Him in Historic Impeachment Trial
“All of these problems are thought to be caused by declining egg quality, rather than a lack of eggs,” said Murphy. Also Read - US Court Seeks Status Report On Visas To Family Members Of H1-B Holders
The researchers used a microscopic worm, Caenorhabditis elegans (C elegans), to study longevity.
For the study, published in the journal Current Biology, they investigated downregulated group of proteins, cathepsin B proteases, that are rare in high-quality eggs and more common in eggs that have begun degrading with age.
The existence of drugs that block these exact proteins provided an opportunity to test their effects.
Another experiment that knocked out the cathepsin B genes entirely succeeded in extending worms fertility by about 10 percent.
“If applied to humans, it could be a three- to six-year extension of your reproductive period,” said Nicole Templeman from Princeton University.
Reproductive decline is a hallmark of aging, but despite its prevalence, interventions to slow the loss of reproductive capacity are lacking, the researchers said. PTI SNE SNE
This is published unedited from the PTI feed.