Real Madrid are the only team who have stopped Atletico Madrid adding a Champions League triumph to their achievements under Diego Simeone and for the fourth year running the the Madrid duo clash again.
Atletico have seen off the giants of the European game past and present, beating AC Milan, Chelsea, Juventus, Bayern Munich and twice knocking out Barcelona, but they have repeatedly fallen to their neighbours.
Real host Atletico in Tuesday’s semi-final, first leg having beaten them 5-3 on penalties in the 2016 final and 4-1 in extra time in the 2014 showpiece when defender Sergio Ramos’s 93rd minute equaliser denied Atletico a first Champions League crown.
Atletico look like they will have defensive problems at the Bernabeu, with Jose Gimenez and Juanfran likely to miss out.
Without any right-back available, Diego Simeone could play Stefan Savic in the position and bring youngster Lucas Hernandez into the middle, although it is unlikely he would break up the Savic-Diego Godin partnership for such a big game.
On the other hand, Zinedine Zidane does not think Real Madrid are favourites in their Champions League semi-final against Atletico Madrid, despite his side holding the upper hand in recent meetings with their city rivals.
Zidane has been boosted by the news that Raphael Varane is fit after a hamstring injury. However, fellow centre-half Pepe is not available. Zidane gave little away about his team selection, refusing to be drawn on whether the likes of Isco or James Rodriguez would replace the injured Gareth Bale.